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Cocaine initially appeared in oral fluid as early as 0. Large variability was noted in earlier studies that based half-lives upon 7 or fewer participants 22 — Sign in via OpenAthens. FDA alerts for all medications. Table 1 Participant demographics. Collection methods that stimulate flow of oral fluid alter salivary pH, reducing drug concentrations due to increased saliva volume and a higher pH from increased bicarbonate excretion 8.





Cocaine was rapidly eliminated from oral fluid with a half-life of approximately 3h, similar to reports after intravenous 0.

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Methyl salicylate topical

Do not apply methyl salicylate topical to your breast area if you are breast-feeding a baby. Sign in via OpenAthens. Pharmacokinetics of cocaine and metabolites in oral fluid Mean maximum oral fluid concentrations C maxtimes of maximum concentration T maxterminal half-lives and areas under the curves AUC 0-last are listed in panel A of Table 3. Five participants received two additional cocaine doses each week to enable comparison of drug concentrations in oral fluid collected by three different methods. Avoid getting this medication in your mouth, nose, rectum, or vagina. Since methyl salicylate topical is used as needed, it does not have a daily dosing schedule.

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Side effects in more detail. Limits of quantification LOQ were 2. All participants had a documented history of cocaine and opioid use, but were not physically dependent on either drug. Splitless injections were made onto an Agilent GC interfaced to an Agilent mass selective detector or an Agilent GC interfaced to a mass selective detector. Sign in via OpenAthens. The elimination half-life is 1—3 hours after a therapeutic dose but may be greater than 12 hours after an overdose see also Table II—